Immunization programs to prevent |

In the developing world, where treatment can be hard to access and safe water is scarce, diarrhea can be deadly. Prevention of diarrheal disease through immunization is a relatively new intervention, but is becoming an essential and lifesaving part of diarrhea control strategies. Vaccines against bacterial causes of diarrhea such as Shigella and enterotoxigenic Escherichia coli (ETEC) are under development, and new vaccines against rotavirus are increasingly available in low-resource settings.
PATH is working with partners to increase access to existing rotavirus vaccines, develop new rotavirus vaccines, and accelerate the development of other new vaccines against causes of diarrhea. To learn more, please visit the PATH website.
UNICEF is the world’s leading agency for vaccine procurement and procures vaccines and immunization supplies on behalf of the GAVI Alliance, which provides subsidized funding for rotavirus vaccine introduction in eligible countries.

Key resources
Below are some key documents on diarrhea vaccines. Please also visit our partners’ websites for more resources.
- Fact sheet: Advancing New Rotavirus Vaccines (available on the PATH website).
- Fact sheet: Developing New Vaccines Against Diarrheal Disease (available on the PATH website).
- Enteric Infections and the Vaccines to Counter Them: Future Directions (948 KB PDF). Vaccine.
- Global Illness and Deaths Caused by Rotavirus Disease in Children (328 KB PDF). Emerging Infectious Diseases.
- Weekly Epidemiological Record: Meeting of the Diarrheal and Enteric Vaccines Advisory Committee (211 KB PDF). World Health Organization (WHO)
- Weekly Epidemiological Record: Rotavirus Vaccines – WHO Position Paper (295 KB PDF). WHO.
Other helpful websites
- PATH’s Vaccine Resource Library
- US Centers for Disease Control and Prevention (CDC): Rotavirus
- CDC: Shigellosis
- Enhanced Diarrheal Disease Control Resource Center
- WHO: ETEC
- WHO: Rotavirus infections
- WHO: Shigella
References
1 Parashar U, Hummelman EG, Bresee JS, Miller MA, Glass RI. Global illness and deaths caused by rotavirus disease in children. Emerging Infectious Diseases. 2003;9(5):565-572.
Photo: PATH/Mike Wang.



